846023-32-3

Basic information

• Product Name: 2-Propenamide, 3-[(4-bromo-3-ethoxyphenyl)amino]-N-(3-chloro-4-fluorophenyl)-2-cyano -
• CAS NO: 846023-32-3
• Molecular Formula: C18H14BrClFN3O2
• Molecular Weight: 438.683
• Mol File: 846023-32-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 3-[(4-bromo-3-ethoxyphenyl)amino]-N-(3-chloro-4-fluorophenyl)-2-cyano -(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 3-[(4-bromo-3-ethoxyphenyl)amino]-N-(3-chloro-4-fluorophenyl)-2-cyano -(846023-32-3)
• EPA Substance Registry System: 2-Propenamide, 3-[(4-bromo-3-ethoxyphenyl)amino]-N-(3-chloro-4-fluorophenyl)-2-cyano -(846023-32-3)

Safety Data

• Hazardous Substances Data: 846023-32-3(Hazardous Substances Data)

Upstream product

• 846023-33-4 4-bromo-3-ethoxyaniline hydrochloride 
• 122-51-0 orthoformic acid triethyl ester 
• 219529-31-4 N-(3-chloro-4-fluoro)phenyl-2-cyanoacetamide 

Downstream Products

• 846023-44-7 6-bromo-7-ethoxy-4-[(3-chloro-4-fluorophenyl)amino]-3-quinolinecarbonitrile 

Relevant articles and documents

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.