846023-58-3Relevant academic research and scientific papers
Five-membered heterocyclic oxo carboxylic acid compound and medical application thereof
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Paragraph 0395-0399; 0475-0479, (2021/05/01)
The invention relates to a five-membered heterocyclic oxo carboxylic acid compound and a medical application thereof. Specifically, the invention relates to a compound, a pharmaceutical salt, a prodrug, a hydrate, a solvate or a crystal form as shown in a formula (I), and also relates to a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the pharmaceutical composition as a secretion regulator of interferon type I, especially as an STING agonist in preparation of medicines for preventing and/or treating I-type interferon related diseases.
Method for synthesizing 2-formylfuran-4-pinacolyl borate
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, (2018/06/26)
The invention discloses a method for synthesizing 2-formylfuran-4-pinacolyl borate. The method comprises the following steps of using furfural as a raw material, reacting with pyrrolidine in the presence of perchloric acid, next, brominating with NBS (N-Bromosuccinimide), finally, reacting with lithium metal and a chlorine-boron reagent, and adding pinacol to subsequently obtain the 2-formylfuran-4-pinacolyl borate. A location effect is good in the method, and a problem that 2-formyl-4-bromofuran can be subsequently obtained only by needing abundant aluminum trichloride to react with a bromineelement to obtain 2-formyl-4,5-dibromofuran and next reacting with butyl lithium to remove position-5 bromine in a previous synthesis method is solved, and the method is suitable for industrialized scale-up production.
