846049-40-9

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 847615-35-4 (1-benzyl-piperidin-4-yl)-(4-bromo-phenyl)-acetonitrile 
• 847615-36-5 (1-benzyl-piperidin-4-yl)-(4-bromo-phenyl)-acetaldehyde 
• 847615-39-8 4-(1-benzyl-piperidin-4-yl)-4-(4-bromo-phenyl)-butyraldehyde 
• 847615-38-7 4-(1-benzyl-piperidin-4-yl)-4-(4-bromo-phenyl)-butyric acid methyl ester 
• 904283-18-7 4-(1-benzyl-piperidin-4-yl)-4-(3'-cyano-biphenyl-4-yl)-butyric acid methyl ester 
• 847615-42-3 2-[3-(1-benzyl-piperidin-4-yl)-3-(4-bromo-phenyl)-propyl]-5,7-dichloro-1H-benzoimidazole 
• 847615-42-3 2-[3-(1-benzyl-piperidin-4-yl)-3-(4-bromo-phenyl)-propyl]-4,6-dichloro-1H-benzoimidazole 
• 904283-02-9 4-(3'-cyano-biphenyl-4-yl)-N-(3,4-difluoro-phenyl)-4-piperidin-4-yl-butyramide 
• 904283-20-1 2-[3-(1-benzyl-piperidin-4-yl)-3-(4-bromo-phenyl)-propyl]-4-chloro-5-fluoro-1H-benzoimidazole 
• 904283-21-2 2-[3-(1-benzyl-piperidin-4-yl)-3-(4-bromo-phenyl)-propyl]-5-fluoro-6-trifluoromethyl-1H-benzoimidazole 
• 904283-01-8 4-(1-benzyl-piperidin-4-yl)-4-(3'-cyano-biphenyl-4-yl)-N-(3,4-difluoro-phenyl)-butyramide 
• 846049-41-0 C₂₆H₂₃BrFN₃ 
• 846049-42-1 C₂₆H₂₂BrClFN₃ 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists

Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.