84628-40-0Relevant academic research and scientific papers
Reductive coupling of phthalic anhydrides with aliphatic ketones by low-valent titanium: Unusual two-to-one coupling for preparation of 3,3-disubstituted phthalides
Kise, Naoki,Yamamoto, Shota,Sakurai, Toshihiko
, (2019/12/24)
The reductive coupling of phthalic anhydrides with acetone by Zn-TiCl4 in THF gave two-to-one and one-to-one coupled products. The coupled products were transformed to 3,3-diisopropyl-, 3-isopropylidene-, and 3-isopropylphthalides. In addition, the reductive coupling of phthalic anhydrides with acetonylacetone by Zn-TiCl4 in THF gave 3-spirocyclopentanylphtalides stereoselectively.
Palladium-catalyzed ring expansion of hydroxy methoxyallenylphthalans as a novel synthetic method for highly substituted 4-isochromanone derivatives
Jeong, Ill-Yun,Shiro, Motoo,Nagao, Yoshimitsu
, p. 85 - 89 (2007/10/03)
The palladium(0)-catalyzed ring expansion reaction using hydroxy methoxyallenylphthalans (3) proceeded smoothly to give highly substituted 4- isochromanone derivatives (4), and treatment of commercially available phthalide (5) with lithium methoxyallene furnished two atom ring-expanded endo-benzoxepin-5-one (8).
A new ring enlargement reaction of γ-lactones to seven-membered cyclic ethers via intramolecular endo-mode cyclisation of the ω-hydroxy allenyl ketone intermediates in situ
Nagao, Yoshimitsu,Jeong, Ill-Yun,Lee, Woo Song,Sano, Shigeki
, p. 19 - 20 (2007/10/03)
Phthalides 1a-f were treated with prop-2-ynylmagnesium bromide followed by treatment with 20% HCl in one pot to give the corresponding seven-membered cyclic ethers, benzoxepins 4a-f.
REACTIONS STEREOSELECTIVES DES ALKYLMAGNESIENS SECONDAIRES AVEC LES ANHYDRIDES ET LACTONES RIGIDES
Canonne, P.,Akssira, M.,Kassou, M.
, p. 4719 - 4722 (2007/10/02)
High stereoselectivity was observed in the reactions of secondary alkylmagnesium compounds with bicyclohept-5-ene-2,3-dicarboxylic anhydride 1 and lactone 2 leading respectively to the formation of trans diastereomeric lactones and erythro primary-secondary diols.
