84637-22-9Relevant academic research and scientific papers
Synthesis of 3,5-diarylisoxazole derivatives and evaluation of in vitro trypanocidal activity
De Souza, Aline A. N.,Xavier, Viviane F.,Coelho, Gleicekelly S.,Sales Junior, Policarpo A.,Romanha, Alvaro J.,Murta, Silvane M. F.,Carneiro, Claudia M.,Taylor, Jason G.
, p. 269 - 277 (2017/12/08)
Chagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylamine and either alkylated at the free hydroxyl group and/or nitrated at the isoxazole ring. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as a reference compound for the in vitro assay and mammalian L929 cells were employed to evaluate cytotoxicity. A majority of the compounds tested were very active and the most active isoxazole against amastigote and trypomastigotes of T. cruzi was slightly more potent than the current medicine benznidazole.
Synthesis and molluscicidal activity of new derivatives of 1-(hydroxy/substituted phenyl)-3-arylpropenones
Nawwar,Haggag,Swellam
, p. 831 - 836 (2007/10/02)
Several 1-(hydroxy/substituted phenyl)propenones were tested as molluscicidal agents among which the 1-(2-hydroxy/substituted phenyl)-3-(2-furyl)propenones 1a-c show the most promising results. In an attempt to improve their activity, new dihydropyrazolo[
Synthesis and Reactions of 1-(2'-Furyl)-3-(substituted-2''-hydroxyphenyl)propanediones
Nair, S. B.,Wadodkar, K. N.
, p. 573 - 574 (2007/10/02)
The title compounds (III) have been synthesised by the base-catalysed Baker-Venkataraman transformation of furoyl esters (II) of substituted 2-hydroxyacetophenones.These propanediones (III) on acid cyclization, bromination, treatment with SO2Cl2, and cond
