84638-83-5Relevant academic research and scientific papers
BACTERIAL EFFLUX PUMP INHIBITORS
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Page/Page column 107; 108; 109, (2018/12/13)
Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
HETEROCYCLIC COMPOUNDS
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Paragraph 0230, (2016/11/07)
Heterocyclic compounds and methods of making them and using them.
Preparation of optically enriched 3-hydroxy-3,4-dihydroquinolin-2(1H)-ones by heterogeneous catalytic cascade reaction over supported platinum catalyst
Szollosi, Gyoergy,Makra, Zsolt,Kovacs, Lenke,Fueloep, Ferenc,Bartok, Mihaly
, p. 1623 - 1629 (2013/07/04)
The development of a novel heterogeneous catalytic asymmetric cascade reaction for the synthesis of tetrahydroquinolines from 2-nitrophenylpyruvates is reported. Optically enriched 3-hydroxy-3,4-dihydroquinolin-2(1H)-ones are prepared by enantioselective hydrogenation of the activated keto group over a Cinchona alkaloid-modified Pt catalyst, reduction of the nitro group and spontaneous cyclization cascade. Acceleration of the enantioselective hydrogenation of the activated keto group over the catalyst modified by Cinchona alkaloids ensured high tetrahydroquinolinone selectivities. The scope of the reaction was checked using twelve substrates. Both yields and enantioselectivities were significantly influenced by the nature and position of the substituents on the phenyl ring. Substituents adjacent to the nitro group considerably increased the product yield, due to their effect on the nitro group′s reduction rate; however, had only a limited effect on enantioselectivities. Copyright
Novel Aryl Piperazine Derivatives With Medical Utility
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Page/Page column 26; 20, (2009/10/01)
This invention provides novel aryl piperazine derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, D2-like and 5-HT2 receptor subtypes, and in particular u
USE OF INDOLYL DERIVATIVES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT ALLERGIC RHINITIS
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Page/Page column 75-77, (2008/06/13)
A method to treat allergic rhinitis is disclosed in which patients are administered certain indolyl compounds.
Unexpected formation of quinolone derivatives in Reissert indole synthesis
Suzuki,Gyoutoku,Yokoo,Shinba,Sato,Yamada,Murakami
, p. 1196 - 1198 (2007/10/03)
The Reissert indole synthesis was found to unexpectedly give 3-hydroxy-1,2,3,4-tetrahydro-2-quinolone derivative 4, sometimes in a high ratio with the expected ethyl indole-2-carboxylate derivatives 3 in a low ratio, depending on the conditions of the catalytic reduction of the intermediate 2-nitrophenylpyruvate 2. This reactivity is characteristic in the preparation of 7-substituted indoles.
