84653-73-6

Upstream product

• 2133-40-6 L-proline methyl ester monohydrochloride 
• 611-73-4 Benzoylformic acid 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 

Downstream Products

• 17199-29-0 (S)-Mandelic acid 
• 611-71-2 (R)-Mandelic Acid 
• 611-71-2 MANDELIC ACID 
• 86868-45-3 (S)-1-((R)-2-Hydroxy-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 84653-74-7 (S)-1-((S)-2-Hydroxy-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 103383-74-0 (8aS)-3-phenyl-3-(2-methyl-2-propenyl)-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo<2,1-c><1,4>oxazine 
• 103383-77-3 methyl (2S)-N-<(1-hydroxy-1-phenyl-3-methyl-3-butenyl)formyl>prolinate 
• 103383-73-9 (3R,8aS)-3-phenyl-3-(2-propenyl)-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo<2,1-c><1,4>oxazine 
• 94726-51-9 methyl (2S,1'S)-N-<(1-hydroxy-1-phenyl-3-butenyl)-formyl>prolinate 
• 103383-79-5 (S)-(+)-3-hydroxy-3-phenyl-5-hexen-2-one 
• 103383-81-9 (+)-3-hydroxy-5-methyl-3-phenyl-5-hexen-2-one 
• 103383-81-9 (-)-3-hydroxy-5-methyl-3-phenyl-5-hexen-2-one 

Relevant academic research and scientific papers

1,2-dicarbonyl compound and synthesis method thereof

The invention discloses a method for synthesizing a 1,2-dicarbonyl compound (1,2-dicarbonylamide or alpha-diketone compound), wherein 1,2-dicarbonyl thioester compounds used as 1,2-dicarbonyl reagentsreact with amine compounds or boric anhydride compounds under appropriate conditions to respectively synthesize a series of 1,2-dicarbonyl compounds. According to the present invention, the 1,2-dicarbonyl compound is obtained by using the stable 1,2-dicarbonyl thioester compound as the dicarbonylation reagent through one-step construction under mild conditions, such that the disadvantage that thetraditional method uses the unstable alpha-carbonyl acyl chloride to synthesize the 1,2-dicarbonyl compound is avoided.

Reversible diastereoselective photocyclization of phenylglyoxylamides of α-amino acid methyl esters to 3-hydroxy β-lactams

Phenylglyoxylamides 1a-m were prepared from enantiomerically pure (1b-l) α-amino acid methyl esters in high yields and irradiated in acetonitrile solutions with λ = 300 nm to give the β-lactams 2a-m as photocyclization products in moderate (38 and 40perce

Stereochimie de la reduction electrochimique d'α-cetoamides optiquement actives II. Electroreduction de benzoylformamides derives de la S(-)-proline

Electrochemical reduction of benzoylformamides derived from S-(-)-proline has been carried out at a mercury cathode in a buffered hydroalcoholic medium; quantitative formation of a mixture of the two epimers of the corresponding mandelamides is observed.D

Diastereoselective Reduction of Chiral α-Ketoamides Derived from (S)-Proline Esters with Sodium Borohydride. Preparation of Optically Active α-Hydroxy Acids

Diastereoselective reductions of chiral α-ketoamides (3) derived from (S)-proline esters (2) with sodium borohydride were examined.Hydrolysis of the reduction products afforded optically active α-hydroxy acids (5) in good enantiomeric excesses (e.e.).The most influential factor of the asymmetric induction was the effect of using a mixed hydroxylic and non-hydroxylic solvent.The degree of asymmetric induction varied considerably with the ratio of alcohol and tetrahydrofuran (THF) in the mixed solvent.With aromatic ketoamides (3), higher asymmetric induction occured in a mixed alcohol-THF solvent than in the corresponding individual solvents.