84659-13-2

Upstream product

• 108-24-7 acetic anhydride 
• 84659-11-0 5',7'-O-benzylidene derivative of methyl 2,3,6-tri-O-acetyl-4-deoxy-4-<(1S)-(1,3,5/2,4,6)-2,3,4-triacetoxy-5-hydroxy-6-hydroxymethyl-1-cyclohexylamino>-α-D-glucopyranoside 
• 84659-11-0 Acetic acid (4aR,5S,6R,7S,8S,8aR)-7,8-diacetoxy-5-((2S,3R,4S,5R,6S)-4,5-diacetoxy-2-acetoxymethyl-6-methoxy-tetrahydro-pyran-3-ylamino)-2-phenyl-hexahydro-benzo[1,3]dioxin-6-yl ester 
• 4097-95-4 Methyl-4-amino-4-deoxy-α-D-glucopyranoside 
• 4181-01-5 Methyl 4-Azido-4-deoxy-α-D-glucopyranoside 
• 77144-73-1 DL-3,4-di-O-acetyl-1,2-anhydro-5,7-O-benzylidene-(1,2,4,6/3,5)-6-hydroxymethyl-1,2,3,4,5-cyclohexanepentol 
• 114779-35-0 (1R,2S,5R,7R,8R,9R,10R,)-8,9-Dibenzyloxy-5-phenyl-4,6,11-trioxatricyclo<8.1.0.0^2.7>undecane 

Relevant academic research and scientific papers

Synthesis and biological activities of methyl oligobiosaminide and some deoxy isomers thereof.

Methyl oligobiosaminide (1) the core structure of oligostatin C, and five analogues, the 6-hydroxy-(2), 2-deoxy- (3), 2-deoxy-6-hydroxy- (4), 3-deoxy- (5), and 3-deoxy-6-hydroxy derivatives (6), were synthesized by coupling the protected pseudo-sugar epoxide 46 with suitable methyl 4-amino-4-deoxy-alpha-D-hexopyranoside derivatives. Compounds 3 and 6 showed notable inhibitory activity against alpha-D-glucosidase and alpha-D-mannosidase, respectively, whereas compound 1 had almost no activity.

SYNTHESIS OF A COMMON STRUCTURAL UNIT OF THE ANTIBIOTIC OLIGOSTATINS

Methyl N--4-amino-4,6-dideoxy-α-D-glucopyranoside, a common structural unit of the antibiotic oligostatins, has been synthesized and characterized as the heptaacetate.