84694-97-3Relevant academic research and scientific papers
Synthesis of enantiopure 1-substituted, 1,2-disubstituted, and 1,4,5-trisubstituted imidazoles from 1,2-amino alcohols
Matsuoka, Yuki,Ishida, Yasuhiro,Sasaki, Daisuke,Saigo, Kazuhiko
, p. 8199 - 8206 (2007/10/03)
A highly versatile method for the preparation of enantiopure 1-substituted, 1,2-disubstituted, and 1,4,5-trisubstituted imidazoles was developed by using the cyclocondensation reaction of a 1,2-dicarbonyl compound, an aldehyde, a 1,2-amino alcohol, and ammonium acetate.
SYNTHESIS OF 2-(2-ARYLETHYL)IMIDAZOLES BY DIRECT ALKYLATION OF 1-(N,N-DIMETHYLAMINOMETHYL)2-LITHIOMETHYLIMIDAZOLE
Tarnchompoo, Bongkoch,Thebtaranonth, Chachanat,Thebtaranonth, Yodhathai
, p. 5779 - 5780 (2007/10/02)
Direct deprotonation of 1-(N,N-dimethylaminomethyl)2-methylimidazole 4 by n-butyllithium yields anion 5 which can readily undergo alkylation reactions.This finding provides immediate access to 2-(2-arylethyl)imidazoles, 1, which are clumsy to prepare by other methods.
