847034-05-3

Upstream product

• 77385-90-1 N,N-dibenzylglycine ethyl ester 
• 847033-98-1 (-)-N-[(E,3R,4S)-4-(dibenzylamino)-5-oxoocta-1,6-dien-3-yl]-1H-pyrrole-2-carboxamide 
• 847034-02-0 (+)-N-[(1S,2R)-1-(N-methoxy-N-methylcarbamoyl)-1-(dibenzylamino)but-3-en-2-yl]-1H-pyrrole-2-carboxamide 
• 847033-97-0 (-)-N-[(1R,5S)-5-(dibenzylamino)-4-oxocyclopent-2-enyl]-1H-pyrrole-2-carboxamide 
• 847034-03-1 (-)-pyrrole 
• 624-83-9 methyl isocyanate 
• 847033-99-2 (-)-ethyl (2S,3R)-2-(dibenzylamino)-3-[(R)-p-toluenesulfinylamino]pent-4-enoate 
• 847034-01-9 (2S,3R)-(-)-3-[(R)-p-toluenesulfinylamino]-2-(dibenzylamino)-N-methoxy-N-methylpent-4-enamide 

Relevant academic research and scientific papers

Improved synthesis of (-)-agelastatin A

Optimization of key steps in the synthesis of the architecturally unique tetracyclic antitumor alkaloid (-)-agelastatin A (1) improved the overall yield of the 11-step process (eight operations) from 9% to 23%. Changing the solvent and using a more effici

ASYMMETRIC SYNTHESIS OF (-)-AGELASTATIN A

The total asymmetric synthesis of the cytotoxic marine metabolite (-)-agelastatin A (1) has been achieved from the C-ring intermediate 4,5-diamino cyclopenten-2-enone (-)-2. This key intermediate was efficiently prepared from the sulfinimine-derived α,β-d

Asymmetric total synthesis of (-)-agelastatin A using sulfinimine (N-sulfinyl imine) derived methodologies

(Chemical Equation Presented) The asymmetric synthesis of the cytotoxic marine metabolite (-)-agelastatin A (1) has been achieved from the C-ring intermediate 4,5-diamino cyclopenten-2-enone (-)-2. This key intermediate was efficiently prepared from the s