847054-10-8

Basic information

• Product Name: 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy] -N-methyl-
• CAS NO: 847054-10-8
• Molecular Formula: C21H16F4N4O3
• Molecular Weight: 448.377
• Mol File: 847054-10-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy] -N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy] -N-methyl-(847054-10-8)
• EPA Substance Registry System: 2-Pyridinecarboxamide, 4-[4-[[[[2-fluoro-5-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy] -N-methyl-(847054-10-8)

Safety Data

• Hazardous Substances Data: 847054-10-8(Hazardous Substances Data)

Upstream product

• 220000-87-3 4-chloro-N-methylpicolinamide 
• 51727-15-2 4-chloro-2-pyridine carboxylic acid chloride hydrochloride 
• 5470-22-4 4-chloropicolinic acid 
• 284462-37-9 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide 
• 69922-27-6 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene 

Relevant articles and documents

KINASE INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF TREATING CANCER

The present invention relates to a compound having the structure of formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X, Y, Z, R, R1, R2, R3, R4, R5, and R6 are as described herein. The present invention also relates to compositions containing the compound having the structure of formula (I), and a method of treating cancer in a subject.

UREA DERIVATIVES AND THEIR USE AS TYROSINKINASE INHIBITORS

The invention relates to novel urea derivatives which inhibit tyrosinkinases, especially TIE-2, and Raf kinases and which are used in the treatment of tumors.