847069-21-0

Basic information

• Product Name: Indeno[1,2-c]pyrazole-3-carboxylic acid, 1-(2-chlorophenyl)-1,4-dihydro-, ethyl ester
• CAS NO: 847069-21-0
• Molecular Formula: C19H15ClN2O2
• Molecular Weight: 338.793
• Mol File: 847069-21-0.mol

Chemical Properties

• CAS DataBase Reference: Indeno[1,2-c]pyrazole-3-carboxylic acid, 1-(2-chlorophenyl)-1,4-dihydro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Indeno[1,2-c]pyrazole-3-carboxylic acid, 1-(2-chlorophenyl)-1,4-dihydro-, ethyl ester(847069-21-0)
• EPA Substance Registry System: Indeno[1,2-c]pyrazole-3-carboxylic acid, 1-(2-chlorophenyl)-1,4-dihydro-, ethyl ester(847069-21-0)

Safety Data

• Hazardous Substances Data: 847069-21-0(Hazardous Substances Data)

Upstream product

• 41052-75-9 o-chlorophenylhydrazine hydrochloride 
• 847069-18-5 ethyl (3-hydroxy-1H-inden-2-yl)(oxo)acetate 
• 83-33-0 inden-1-one 

Downstream Products

• 847069-26-5 1-(2-chloro-phenyl)-4-oxo-1,4-dihydro-indeno[1,2-c]pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives

A series of new pyrazole-condensed 6,5,5 tricyclic compounds were synthesized and tested to evaluate their binding affinities at both central (CBR) and peripheral (PBR) benzodiazepine receptors. Some 1-aryl-5- phenylpyrazole derivatives were also prepared and tested for comparison with their corresponding rigid tricyclic analogs. Among the newly synthesized 1-aryl-1,4-dihydro-indeno[1,2-c]pyrazoles bearing both an ethoxycarbonyl group at position 3 and a carbonyl function at the position 4, compound 4b emerged as a new potent (IC50 = 26.4 nM) and selective CBR ligand. The 4-oxo-1-aryl-1,4-dihydro-indeno[1,2-c]pyrazole diethylamide derivative 14a was instead identified as a relatively potent (IC50 = 124 nM) but highly selective PBR ligand.