84707-94-8Relevant academic research and scientific papers
SOLUTION SYNTHESIS OF N-METHYLATED PEPTIDES BY THE DIPHENYL PHOSPHINIC MIXED ANHYDRIDE PROCEDURE
Galpin, I. J.,Mohammed, A. K.,Patel, A.
, p. 1685 - 1690 (2007/10/02)
A proton NMR method has been used to monitor racemisation during the coupling of N-methylated amino acids by the diphenylphosphinic mixed anhydride procedure.No racemisation was observed when urethane protection employed, but use of the benzoyl group led extensive racemisation.The reagent was subsequently used for the assembly of several extensively N-methylated peptides.
Assessment of Racemisation in N-Alkylated Amino-acid Derivatives during Peptide Coupling in a Model Dipeptide System
Davies, John S.,Mohammed, A. Karim
, p. 2982 - 2990 (2007/10/02)
N.m.r. analysis of diastereoisomeric benzoyl dipeptide esters has been used to monitor racemisation during the coupling of benzoyl-N-alkylated amino-acids to alanine and valine methyl esters.Results confirm the greater susceptibility of these amino-acids
