847148-17-8

Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-1-FLUORO-4-METHYLSULFONYLBENZENE is used as an intermediate in the synthesis of pharmaceuticals for its unique chemical and physical properties.
Used in Agrochemical Industry:
2-CHLORO-1-FLUORO-4-METHYLSULFONYLBENZENE is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used in Dyes and Pigments Production:
2-CHLORO-1-FLUORO-4-METHYLSULFONYLBENZENE is utilized in the production of dyes and pigments, offering a range of color options for various industries.
Used in Materials Science:
2-CHLORO-1-FLUORO-4-METHYLSULFONYLBENZENE has potential applications in materials science due to its unique properties, which can be harnessed to create innovative materials for different uses.
It is important to handle 2-CHLORO-1-FLUORO-4-METHYLSULFONYLBENZENE with caution and adhere to safety protocols due to its hazardous nature.

Upstream product

• 387358-51-2 2-fluoro-5-(methylsulfonyl)aniline 
• 847148-16-7 (3-chloro-4-fluorophenyl)(methyl)sulfane 

Downstream Products

• 942268-33-9 methyl 4-chloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]benzoate 
• 934241-12-0 [3-[2-chloro-4-(methylsulfonyl)phenoxy]-5-(trifluoromethyl)phenyl] acetic acid 
• 934241-05-1 {3-chloro-5-[2-chloro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid 
• 942268-42-0 2-chloro-1-[(5-chloro-2-methoxyphenyl)thio]-4-(methylsulfonyl)benzene 
• 847148-57-6 {2-[2-chloro-4-(methylsulfonyl)phenoxy]-4,5-difluorophenoxy}acetic acid 
• 847149-15-9 {2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid 
• 847148-56-5 {4,5-dichloro-2-[2-chloro-4-(methylsulfonyl)phenoxy]phenoxy}acetic acid 
• 917761-29-6 bis(2-chloro-4-methanesulfonyl-benzene)disulfide 
• 934241-70-0 ethyl {4-chloro-3-[2-chloro-4-(methylsulfonyl)phenoxy]phenyl}acetate 

Relevant academic research and scientific papers

Indolizine Derivatives

Compounds of formula (I) are ligands of the CRTH2 receptor and are useful in the treatment of respiratory disease: Formula (I) wherein R1, R2, R3 and R4 each independently are hydrogen, C1C6/sub

CRTH2 ANTAGONISTS

The following compounds are CRTH2 antagonists, useful in treatment of respiratory disease: [3-(2,4-dichlorophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(2-fluoro-4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methanesulfonyl-2-trifluoromethylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, (R)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, [3-(4-ethanesulfonylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, (S)-2-[6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]propionic acid, ethanesulfonylaminobenzenesulfonyl)-6-fluoro-2-methyiindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methanesulfonylphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(2-chloro-4-methanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(4-methanesulfonylbenzyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-chlorobenzyl)-7-cyano-2-methylindolizin-1-yl]acetic acid, [6-cyano-3-(6-fluoroquinolin-2-ylmethyl)-2-methylindolizin-1-yl]acetic acid, [6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [7-chloro-6-fluoro-3-(4-methoxyphenylsulfanyl)-2-methylindolizin-1-yl]acetic acid, [3-(4-bromophenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid, and [3-(4-cyclopropylsulfamoylphenylsulfanyl)-6-fluoro-2-methylindolizin-1-yl]acetic acid.

IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR

Compounds of formula (I) are CRTH2 antagonists, useful in the treatment of, for example, asthma, chronic obstructive pulmonary disease, rhinitis, allergic airway syndrome, and allergic rhinobronchitis. Formula (I) wherein R1, R2. R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, halo, -S(O)nR10, -SO2N(R10)2, -N(R10)2, -C(O)N(R10)2, -NR10C(O)R9, -CO2R10, -C(O)R9, -NO2, -CN or -OR11; wherein each R9 is independently C1-C6alkyl, aryl, heteroaryl; R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl; R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl or a group -SO2R10 ; n is 0, 1 or 2; R5 is C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, C1-C6alkenyl, C1-C6alkynyl, optionally substituted aryl, or optionally substituted heteroaryl; R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6alkyl ; R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and X is -CHR6-, -S(O)n-, -C(O)-, -NR6SO2- or -SO2NR6- wherein n is 0, 1 or 2.

BENZAMIDE DERIVATIVES THAT ACT UPON THE GLUCOKINASE ENZYME

Compounds of Formula: (I); wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substitut

SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to substituted acids of formula (I), where T,W,X,Y,Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.

PHENOXIACETIC ACID DERIVATIVES

The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, s