847152-70-9Relevant academic research and scientific papers
Synthesis of a C3-symmetric macrocycle with alternating sugar amino acid and tyrosine residues
Billing, Johan F.,Nilsson, Ulf J.
, p. 991 - 993 (2005)
A C3-symmetric macrocycle with alternating sugar amino acid and tyrosine residues was synthesized in seven steps from tyrosine tert-butyl ester and a sugar amino acid precursor derived from D-glucosamine. An Fmoc-protected D-glucosamine derivative was oxidized at C-6 to give the sugar amino acid, which was immediately coupled to tyrosine tert-butyl ester to produce an orthogonally protected building block. This building block was subsequently elongated to the trimer via the dimer, and finally cyclized to give the C3-symmetric macrocycle.
