847255-88-3Relevant academic research and scientific papers
Synthesis of anti-inflammatory, analgesic and COX-II inhibitory activities of indolylpyrazolines
Kumar, Ashok,Archana,Sharma, Shalabh,Malik, Nidhi,Sharma, Preeti,Kaushik, Kavita,Saxena, Kuldeep Kumar,Srivastava, Virendra Kishore,Verma,Sharma, Himansahu,Gupta,Gupta, Vipul,Agarwal
, p. 1532 - 1536 (2007/10/03)
Some 1-[N-phenylsulphonyl-3-(2′-substituted-3′-sulphonyl- 5′-methoxyindol-3′-yl)]-2-pyrazolines 7,8 and 1-[N-benzoyl-3- (2′-substituted-3′-sulphonyl-5′-methoxyindol-3yl)] -2-pyrazolines 5,6 have been synthesized by the reaction of 3-(2′- substituted-3′-sulphonyl-5′-methoxyindol-3′-yl)-2-pyrazolines 3,4 with benzenesulphonylehloride and benzoyl chloride respectively. The compounds of this series are screened for their anti-inflammatory, analgesic and COX-II inhibitory activities and compared with standard drugs, aspirin and indomethacin. The most active compound of this series is 1-[N-phenylsulphonyl-3- (2′-phenyl-3′-sulphonyl-5′-methoxyindol-3′-yl)] -2-pyrazoline 8.
