847256-40-0Relevant academic research and scientific papers
Tetrahydro-1,5-benzoxazepines and tetrahydro-1H-1,5-benzodiazepines by a tandem reduction-reductive amination reaction
Bunce, Richard A.,Smith, Christopher L.,Lewis, Jason R.
, p. 963 - 970 (2004)
A tandem reduction-reductive amination reaction has been applied to the synthesis of (±)-4-alkyl-2,3,4,5-tetrahydro-1,5-benzoxazepines and (±)-4-alkyl-1-benzoyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepines. The nitro aldehydes and ketones required for 1,5-be
Chiral N,N Ligands Enabling Palladium-Catalyzed Enantioselective Intramolecular Heck–Matsuda Carbonylation Reactions by Sequential Migratory and CO Insertions
Carmona, Rafaela C.,K?ster, Otto D.,Correia, Carlos Roque Duarte
supporting information, p. 12067 - 12070 (2018/09/11)
Unprecedented enantioselective intramolecular Heck carbonylation reactions of arenediazonium salts were enabled by a chiral N,N ligand. This reaction constitutes the first enantioselective Heck carbonylation that proceeds through migratory insertion followed by CO insertion. The enantioenriched functionalized dihydrobenzofurans were obtained in good to high yields and enantiomeric ratios of up to 98:2 under mild and operationally simple reaction conditions.
