847258-23-5Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of (E)- and (Z)-styryl-2-acetoxyphenyl sulfides and sulfones as cyclooxygenase-2 inhibitors
Reddy, M.V. Ramana,Mallireddigari, Muralidhar Reddy,Pallela, Venkat R.,Venkatapuram, Padmavathi,Boominathan, Rengasamy,Bell, Stanley C.,Reddy, E. Premkumar
, p. 1715 - 1723 (2008/02/02)
A new series of styryl acetoxyphenyl sulfides and sulfones possessing (E)- and (Z)-configurations were designed and prepared by stereospecific syntheses. All these compounds were evaluated for their ability to inhibit COX-2 enzyme in vitro. Structure-acti
(Z)-styryl acetoxyphenyl sulfides as cyclooxygenase inhibitors
-
Page column 10, (2008/06/13)
Compounds of the formula are provided wherein R1, R2, R3and R4are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8alkyl, C1-C6alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflammation and cyclooxygenase-mediated disorders.
