847259-17-0Relevant academic research and scientific papers
Synthesis of bis-spiro cyclopropanes based on Meldrum's acid by milling
Kashani, Elmira,Noroozi Pesyan, Nader,Tun?, Tuncay,Sahin, Ertan
, p. 249 - 256 (2015/03/31)
Reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) with various solid aldehydes in the presence of cyanogen bromide and solid sodium ethoxide (EtONa) leads to the selective and efficient formation of bis-spiro cyclopropanes based on Meldrum's acid at the range of 0 °C to room temperature. The products were obtained in good to excellent yields. Structure elucidation is carried out by 1H NMR, 13C NMR, FT-IR spectroscopy, mass analyses and X-ray crystallography techniques. A possible mechanism for the formation of products is also discussed under solvent-free condition.
AROMATIC RING COMPOUND
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Paragraph 0332; 0333, (2015/01/18)
Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Synthesis and biological evaluation of arylidene analogues of Meldrum's acid as a new class of antimalarial and antioxidant agents
Sandhu, Harmeet S.,Sapra, Sameer,Gupta, Mukesh,Nepali, Kunal,Gautam, Raju,Yadav, Sunil,Kumar, Raj,Jachak, Sanjay M.,Chugh, Manoj,Gupta, Manish K.,Suri, Om P.,Dhar
experimental part, p. 5626 - 5633 (2010/09/11)
A series of arylidene analogues of Meldrum's acid were synthesized and evaluated for in vitro antimalarial and antioxidant activities for the first time. The influence of various physico-chemical parameters such as dielectric constant (), donor number (DN
Diels-alder reactions with cyclic sulfones: VII. Synthesis of 1-benzothiophene 1,1-dioxide derivatives
Andreev,Shul'ts,Volkov,Shakirov,Bagryanskaya,Gatilov,Tolstikov
, p. 854 - 865 (2007/10/03)
5-Arylmethylene-2,2-dimethyl-1,3-dioxane-4,6-diones reacted with 5-isopropenyl-2,3-dihydrothio-phene 1,1-dioxide to give the corresponding ortho-addition products, 5-aryl-2',2',7-trimethyl-3,3a,5,6-tetra-hydro-2H- spiro[1-benzothiophene-4,5'-[1,3]dioxane]-4',6'-dione 1,1-dioxides. Their aminolysis resulted in opening of the 1,3-dioxane ring and formation of 4-carbamoyl-7-methyl-2,3,3a,4,5,6-hexahydro-1-benzo-thiophene-4-carboxylic acid 1,1-dioxide whose structure was determined by X-ray analysis. Reactions of the spiro adducts with amines and hydrazine hydrate afforded the corresponding mono- or dicarboxylic acid monoamides (hydrazide).
