847359-70-0Relevant articles and documents
A role for fucose α(1-2) galactose carbohydrates in neuronal growth
Kalovidouris, Stacey A.,Gama, Cristal I.,Lee, Lori W.,Hsieh-Wilson, Linda C.
, p. 1340 - 1341 (2005)
We report a fucose α(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucα(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we sho
Carbohydrate modifiers of neuronal growth
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Page/Page column 2; 6; 11; sheet 1; 10, (2008/06/13)
Fucose galactose carbohydrates have been shown to induce neuronal outgrowth. The invention includes methods of inducing neuronal outgrowth using carbohydrates, assemblies, and polymers bearing fucose-galactose moieties, as well as associated proteins. Cell growth can be stimulated in cells in culture or in cells within an animal or patient. Growth stimulation has application to understanding and treatment of neurodegenerative diseases including, for example, Parkinson's disease, Alzheimer's disease and multiple sclerosis and conditions such as stroke, brain injury and spinal cord injury. Such compounds, polymers, and assemblies also can be used to increase neural stem or progenitor cells in culture or in an animal, and to enervate engineered tissue.