847361-79-9

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 1158963-69-9 4,5-dehydroleucine methyl ester hydrochloride 
• 847361-77-7 methyl N-(diphenylmethylene)-4-methylenenorvalinate 
• 501-53-1 benzyl chloroformate 
• 87325-47-1 (2S)-2-tert-butoxycarbonylamino-4-methyl-4-pentenoic acid 

Downstream Products

• 1158963-75-7 C₁₄H₁₇NO₅ 
• 1158963-84-8 C₁₄H₁₇NO₅ 
• 847361-81-3 methyl N-[(benzyloxy)carbonyl]-3-(1-methylcyclopropyl)alaninate 

Relevant academic research and scientific papers

AMINOCARBAMOYL COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS

The present invention relates to compounds of formula (II) wherein R1-R5, X and L are as described herein, and pharmaceutically acceptable salts thereof, compositions including the compounds and methods of using the compounds, particularly in the treatment and prophylaxis of coronavirus infection.

Peptides containing γ,δ,-dihydroxy-L-leucine

(Chemical Equation Presented) (±)-Dehydroleucine was prepared and resolved by porcine kidney acylase. Under the conditions of the Sharpless asymmetric dihydroxylation (SAD), employing AD-mix-α, Nα- carbobenzyloxy-(2S)-4,5-dehydroleucine methyl ester (16)

CATHEPSIN INHIBITORS

This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3 and R4 are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis.