847370-40-5

Basic information

• Product Name: (2-chloro-5-phenylpyridin-3-yl)methanol
• Synonyms: (2-chloro-5-phenylpyridin-3-yl)methanol
• CAS NO: 847370-40-5
• Molecular Weight: 219.671
• Mol File: 847370-40-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-chloro-5-phenylpyridin-3-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-chloro-5-phenylpyridin-3-yl)methanol(847370-40-5)
• EPA Substance Registry System: (2-chloro-5-phenylpyridin-3-yl)methanol(847370-40-5)

Safety Data

• Hazardous Substances Data: 847370-40-5(Hazardous Substances Data)

Upstream product

• 176433-57-1 2-chloro-5-phenyl-3-pyridine carboxaldehyde 

Relevant articles and documents

Synthesis and biological activities of nicotinaldehyde based azlactones

A series of nicotinaldehyde based azlactones 3a-g, 6a-f, 11a-d, 16b-c, and 16e-f have been prepared and screened for their free radicals scavenging, a-glucosidase inhibitory and anti-proliferative activities on cell lines, namely lung adenocarcinoma (A549), human breast cancer (MCF7) and human epithelial cervical cancer (HeLa). Compound 3g is the most potent α-glucosidase inhibitor followed by compounds 6b and 6a. Compound 11b is the better DPPH and ABTS+radical scavenger. Compounds 11c-d and 16f show anti-proliferative activity on all the tested cell lines. However, compounds 16c and 16e display anti-proliferative activity on MCF7 and HeLa cell lines.

Synthesis and structure-activity relationships of pyridinyl-1 H -1,2,3-triazolyldihydroisoxazoles as potent inhibitors of tubulin polymerization

Three series of compounds; pyridinyl-1H-1,2,3-triazoles, pyridinyl-1H-1,2,3-triazolylisoxazoles and pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles with TMP moiety were designed, synthesized and screened for their anti-cancer and anti-tubulin properties. By sequentially designing three series of compounds comprising of dihydroisoxazole in the linker, a small substituent like chlorine on one side (R1) and aromatic group (R) on the pyridine ring, we have optimized the anti-cancer as well as anti-tubulin activity. Pyridinyl-1H-1,2,3-triazolyldihydroisoxazoles 28b and 28c were found to be potent anti-cancer agents against all the cell lines tested with a concomitant accumulation of cells in the G2/M phase of the cell cycle. Molecular modeling suggests that the trimethoxyphenyl ring in 28b and 28c occupies the cholchicine binding domain of β-tubulin, whereas, the dihydroisoxazole extends towards the interface of α/β-tubulin.