847443-11-2Relevant academic research and scientific papers
Synthesis and SAR of novel 1,1-dialkyl-2(1H)-naphthalenones as potent HCV polymerase inhibitors
Bosse, Todd D.,Larson, Daniel P.,Wagner, Rolf,Hutchinson, Doug K.,Rockway, Todd W.,Kati, Warren M.,Liu, Yaya,Masse, Sherie,Middleton, Tim,Mo, Hongmei,Montgomery, Debra,Jiang, Wen,Koev, Gennadiy,Kempf, Dale J.,Molla, Akhter
, p. 568 - 570 (2008/09/17)
A series of gem-dialkyl naphthalenone derivatives with varied alkyl substitutions were synthesized and evaluated according to their structure-activity relationship. This investigation led to the discovery of potent inhibitors of the hepatitis C virus at l
ANTI-INFECTIVE AGENTS
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Page/Page column 195-196, (2010/02/11)
Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
Anti-infective agents
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Page/Page column 92, (2008/06/13)
Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.
