84746-24-7

Basic information

• Product Name: 2,2'-(1,4-Piperazinediyl)bis-pyrimidine
• Synonyms: 2,2'-(1,4-Piperazinediyl)bis-pyrimidine;Buspirone EP Impurity G;2-(4-pyrimidin-2-ylpiperazin-1-yl)pyrimidine
• CAS NO: 84746-24-7
• Molecular Formula: C₁₂H₁₄N₆
• Molecular Weight: 242.27976
• Mol File: 84746-24-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 273-274 °C
• Boiling Point: 480.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.276±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly, Heated)
• PKA: 5.17±0.33(Predicted)
• CAS DataBase Reference: 2,2'-(1,4-Piperazinediyl)bis-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-(1,4-Piperazinediyl)bis-pyrimidine(84746-24-7)
• EPA Substance Registry System: 2,2'-(1,4-Piperazinediyl)bis-pyrimidine(84746-24-7)

Safety Data

• Hazardous Substances Data: 84746-24-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 84746-24-7 differently. You can refer to the following data:
1. 2,2'-(1,4-Piperazinediyl)bis-pyrimidine is an impurity of Buspirone (B689850), an non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist.
2. 2,2’-(1,4-Piperazinediyl)bis-pyrimidine is an impurity of Buspirone (B689850), an non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist.

Upstream product

• 110-85-0 piperazine 
• 1722-12-9 2-chloropyrimidine 

Relevant articles and documents

Synthesis and biological activity of some novel trifluoromethyl-substituted 1,2,4-triazole and bis(1,2,4-Triazole) mannich bases containing piperazine rings

A series of trifluoromethyl-substituted 1,2,4-triazole Mannich base 6 and bis(1,2,4-triazole) Mannich base 7 containing pyrimidinylpiperazine rings via the Mannich reaction were synthesized and characterized by infrared (IR), 1H nuclear magnetic resonance (NMR), and elemental analysis. The fungicidal tests indicated that most of compounds 6 and 7 possessed excellent fungicidal activity. Among 19 novel compounds, some showed superiority over commercial fungicides Dimethomorph, Thiophanate-methyl, Iprodione, and Zhongshengmycin. Some compounds also exhibited favorable herbicidal activity in the preliminary studies. On the basis of the comparative molecular field analysis (CoMFA), five novel compounds were subsequently synthesized, their activities were estimated fairly accurately, and compounds 6-A1 and 7-A2 displayed good fungicidal activity against Pseudoperonospora cubensis (96.9 and 84.9%) as 6h and 7c, respectively.