847465-88-7Relevant academic research and scientific papers
Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents
Singh, Pragya,Faridi, Uzma,Srivastava, Suchita,Kumar, Jonnala Kotesh,Darokar, Mahender Pandurang,Luqman, Suaib,Shanker, Karuna,Chanotiya, Chandan Singh,Gupta, Atul,Gupta, Madan Mohan,Negi, Arvind Singh
experimental part, p. 242 - 246 (2010/08/04)
A series of novel podophyllotoxin (PDT) analogues was synthesized in which the lactone moiety was shifted to C ring. Some of the derivatives were also synthesized with modified A ring. Analogues 23 and 25 exhibited potent in vitro cytotoxicity against colon cancer (CaCO2) cell line. p-Demethylated E-ring analogues exhibited better potency than the corresponding methylated analogues. These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100 μg/ml) than their cytotoxicity values.
