847468-95-5

Upstream product

• 205380-30-9 (R)-2-(2-hydroxy-1-phenylethyl)-1H-isoindole-1,3(2H)-dione 
• 56613-80-0 D-2-phenylglycinol 
• 503631-22-9 3-Butyl-3-hydroxy-2-((R)-2-hydroxy-1-phenyl-ethyl)-2,3-dihydro-isoindol-1-one 

Relevant academic research and scientific papers

Studies on the diastereoselective reductive alkylation of (R)-phenylglycinol derived phthalimide: Observation of stereoelectronic effects

Full details of a flexible approach to N-protected (R)-3-alkyl-isoindolin- 1-ones 13 via diastereoselective reductive-alkylation are described, with emphasis on the stereochemical outcome of the key diastereoselective reactions. Additional experiments allowed finding remarkable stereoelectronic effects on the reductive ring-opening reactions.