84754-35-8Relevant academic research and scientific papers
Ring Closure in Quinonoylmethane Dyes; On the Reactivity of the Cyclohexyl Moiety in 2-Chloro-3--1,4-naphthoquinone
Schelz, Dieter,Rotzler, Niklaus
, p. 1990 - 1995 (1982)
The reactive title compound (1a, X= F, R1= C6H11, R2= Cl) was obtained from the reaction of 1-cyclohexyl-6-fluoro-2,3-dimethylquinoxalinium perchlorate with 2,3-dichloro-1,4-naphyoquinone.Upon treatment with pyridine and acetic acid in acetone and separation of the desired naphtophenazinone 2a, an unexpected azepinoquinoxaline 4a was isolated.The structure of 4a was determined by its mass and 360-MHz-1H-NMR. spectra in connenction with decoupling experiments.
Cycloalkyl or benzyl-6-substituted-quinoxalinediones
-
, (2008/06/13)
Heterocyclic dihydroxyquinoxaline compounds having the formula STR1 wherein R 1 is C 1-12 -alkyl, which may optionally be substituted by hydroxy, formyl, carboxy, carboxylic esters, amides or amines, C 3-8 -cycloalkyl, aryl, aralkyl; and wherein R 6 is, hydrogen, halogen, CN, CF 3, NO 2, or OR'', wherein R'' is C 1-4 -alkyl and R 5, R 7 and R 8 is hydrogen, provided R 6 is not CF 3, OCH 3, NO 2, C 1 or Br when R 1 is CH 3 ; orR 6 and R 7 independently are NO 2, halogen, CN, CF 3, or OR'', wherein R'' is C 1-4 -alkyl, and R 5 and R 8 are each hydrogen; orR 5 and R 6 together form a further fused aromatic ring, which may be substituted with halogen, NO 2, CN, CF 3 or OR'', wherein R'' is C 1-4 -alkyl, and R 7 and R 8 independently are hydrogen, halogen, CN, CF 3, NO 2 or OR'', wherein R'' is C 1-4 -alkyl; orR 7 and R 8 together form a further fused aromatic ring, which may be substituted with halogen, NO 2, CN, CF 3 or OR'', wherein R'' is C 1-4 -alkyl, and R 5 and R 6 independently are hydrogen, halogen, CN, CF 3, NO 2 or OR'', wherein R'' is C 1-4 -alkyl.The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use.The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.
