847546-83-2

Upstream product

• 189763-57-3 1-(3-fluoro-4-(piperazine-1-yl)phenyl)ethane-1-one 
• 905275-65-2 4'-fluoro-4-(methylsulfonyl)-2-biphenylcarboxylic acid 

Downstream Products

• 909416-64-4 1-[3-fluoro-4-(4-{[4'-fluoro-4-(methylsulfonyl)-2-biphenylyl]carbonyl}-1-piperazinyl)phenyl]ethanol 

Relevant academic research and scientific papers

ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Substituted acylpiperazine derivatives

The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.