847546-84-3Relevant academic research and scientific papers
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
Pinard, Emmanuel,Alberati, Daniela,Borroni, Edilio,Fischer, Holger,Hainzl, Dominik,Jolidon, Synese,Moreau, Jean-Luc,Narquizian, Robert,Nettekoven, Matthias,Norcross, Roger D.,Stalder, Henri,Thomas, Andrew W.
scheme or table, p. 5134 - 5139 (2009/05/26)
Screening of the Roche compound library led to the identification of the benzoylpiperazine 7 as a structurally novel GlyT1 inhibitor. The SAR which was developed in this series resulted in the discovery of highly potent compounds displaying excellent sele
ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS
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Page/Page column 108-109, (2010/11/23)
The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.
Substituted acylpiperazine derivatives
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Page/Page column 26; 63, (2008/06/13)
The invention relates to compounds of formula wherein the substituents are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention further relates to methods for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
