84757-50-6

Upstream product

• 64200-22-2 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one 
• 249278-28-2 2,4,6-trihydroxyacetophenone monohydrate 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 

Downstream Products

• 7555-80-8 pentamethyl morin 
• 480-16-0 morin 
• 84757-51-7 2-(2,4-Dimethoxy-phenyl)-5,8-dihydroxy-3,7-dimethoxy-chromen-4-one 
• 19056-75-8 2-(2,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one 
• 71787-04-7 5-hydroxy-3,7,8,2',4'-pentamethoxyflavone 

Relevant academic research and scientific papers

The total synthesis of (±)-sanggenol F

A concise and efficient total synthesis of sanggenol F (1) in racemic form has been completed via a sequence of 15 steps with an overall yield of 3.1%, starting from commercially available 2,4,6-trihydroxyacetophenone. Meanwhile, a semisynthesis of sanggenol F racemate has also been achieved in 11.1% overall yield via 7 steps with naturally-occurring morin (2) as the starting material. One step and a stepwise approach were employed to construct the two prenyl side chains at 2- and 6-positions by Claisen rearrangement reaction.

Synthesis of 5-Hydroxy-3,7,8,2',4'-pentamethoxyflavone

The title flavone (II) has been synthesised starting from 2'-hydroxy-2,4,4',6'-tetramethoxychalkone (VII).VII on treatment with H2O2 in the presence of alkali gives 3-hydroxy-5,7,2',4'-tetramethoxyflavone (III), which on methylation affords 3,5,7,2',4'-pe