84759-22-8Relevant academic research and scientific papers
1H-1,3-benzazaphospholes: The organometallic route and a new three-step synthesis with reductive ring closure
Bansal, Raj K.,Gupta, Neelima,Heinicke, Joachim,Nikonov, George N.,Saguitova, Farida,Sharma, Dinesh C.
, p. 264 - 269 (2007/10/03)
Primary and N-secondary 2-phosphanylanilines were synthesized via metallation of 2-bromoanilines, coupling with CIP(NMe2)2, alcoholysis and reduction with LiAlH4, and subsequently reacted with formimidoester hydrochloride to give 1,3-benzazaphospholes. For 1H-1,3-benzazaphospholes, a shorter alternative three-step synthesis was developed, based on N-acylation of 2-bromoaniline, NiCl2-catalyzed arylation of triethyl phosphite and a new reductive cyclization of amidophosphonic acid ester with excess LiAlH4.
C-METALLIERUNG AN PHOSPHAAROMATEN-2-LITHIO-1-METHYL-1,3-BENZAAZAPHOSPHOL
Heinicke, J.,Tzschach, A.
, p. 3643 - 3646 (2007/10/02)
1-Methyl-1,3-benzaazaphospholes are described; the 2H derivate and t-BuLi give the title compound, characterized by reaction with CO2 and Me3SiCl; NMR data confirm the results.
