847591-62-2 Usage
Uses
Used in Pharmaceutical Industry:
ICG-001 is used as a therapeutic agent for the treatment of various diseases, including cancer, by inhibiting the β-catenin-Tcf-mediated transcription pathway, which plays a crucial role in cell proliferation, differentiation, and tumorigenesis.
Used in Cancer Research:
ICG-001 is used as a research tool in cancer biology to study the role of the Wnt/β-catenin signaling pathway in tumor development and progression. By inhibiting the β-catenin/CBP interaction, ICG-001 helps researchers understand the molecular mechanisms underlying cancer growth and identify potential therapeutic targets.
Used in Drug Development:
ICG-001 serves as a lead compound in the development of novel drugs targeting the Wnt/β-catenin signaling pathway. Its ability to inhibit the β-catenin-Tcf-mediated transcription makes it a promising candidate for the treatment of various cancers and other diseases associated with the dysregulation of this pathway.
Biochem/physiol Actions
Cell permeable: yes
References
1) Emami?et al.?(2004),?A small molecule inhibitor of β-catenin/CREB-binding protein transcription;? Proc. Natl. Acad. Sci. USA,?101?12682
2) Zhou?et al.?(2012), Interactions?between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);??J. Biol. Chem.,?287?7026
Check Digit Verification of cas no
The CAS Registry Mumber 847591-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,5,9 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 847591-62:
(8*8)+(7*4)+(6*7)+(5*5)+(4*9)+(3*1)+(2*6)+(1*2)=212
212 % 10 = 2
So 847591-62-2 is a valid CAS Registry Number.
847591-62-2Relevant academic research and scientific papers
SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE
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, (2014/03/22)
The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchym
Solution-phase synthesis of ICG-001, a β-turn peptidomimetic molecule inhibitor of β-catenin-Tcf-mediated transcription
Piergentili, Alessandro,Del Bello, Fabio,Gentili, Francesco,Giannella, Mario,Quaglia, Wilma,Vesprini, Cristian,Thomas, Russell J.,Robertson, Graeme M.
, p. 12912 - 12916 (2008/03/28)
The solution-phase synthesis of the β-turn peptidomimetic ICG-001, a selective inhibitor of Wnt/β-catenin signalling, which has been found to be important for both initiation and progression of cancers of different tissues and has been exploited as an ext
