84762-64-1Relevant academic research and scientific papers
Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors
Smith II, Leon,Piatnitski, Evgueni L.,Kiselyov, Alexander S.,Ouyang, Xiaohu,Chen, Xiaoling,Burdzovic-Wizemann, Sabina,Xu, Yongjiang,Wang, Ying,Rosler, Robin L.,Patel, Sheetal N.,Chiang, Hui-Hsien,Milligan, Daniel L.,Columbus, John,Wong, Wai C.,Doody, Jacqueline F.,Hadari, Yaron R.
, p. 1643 - 1646 (2007/10/03)
A novel class of pyrimido[4,5-b]-1,4-benzoxazepines is described as inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase. Two compounds display potent EGFR inhibitory activity of less than 1 μM in cellular phosphorylation assays (IC50 0.47-0.69 μM) and are highly selective against a small kinase panel. Such compounds demonstrate anti-EGFR activity within a class that is different from any known EGFR inhibitor scaffolds. They also provide a basis for the design of kinase inhibitors with the desired selectivity profile.
A STUDY OF NITROGEN- AND OXYGEN-CONTAINING HETEROCYCLES. 42. PYRIMIDO- AND PYRIDO-1,4-BENZOXAZEPINES
Levkovskaya, L. G.,Sazonov, N. V.,Grineva, N. A.,Mamaeva, I. E.,Serochkina, L. A.,Safonova, T. S.
, p. 100 - 103 (2007/10/02)
The reaction of o-haloamino derivatives of pyrimidine and pyridine with o-hydroxybenzaldehyde and its derivatives leads to the formation of tricyclic 1,4-oxazepine systems.Syntheses are reported for derivatives of pyrimido- and pyrido-1,4-be
