84766-98-3Relevant academic research and scientific papers
Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells
Bourguet, Carine B.,Boulay, Pierre-Luc,Claing, Audrey,Lubell, William D.
supporting information, p. 3361 - 3365 (2014/07/22)
A set of azapeptides was designed based on the Ala-Val-Pro-Ile peptide (derived from Smac protein) to activate caspase-9 and induce apoptosis in breast cancer cells. The diversity-oriented synthesis of the aza-peptides 5-9 was accomplished by alkylation o
Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis
Bourguet, Carine B.,Proulx, Caroline,Klocek, Sophie,Sabatino, David,Lubell, William D.
experimental part, p. 284 - 296 (2011/03/20)
Aza-peptides have been used as tools for studying SARs in programs aimed at drug discovery and chemical biology. Protected aza-dipeptides were synthesized by a solution-phase submonomer approach featuring alkylation of N-terminal benzophenone semicarbazon
