847727-77-9Relevant academic research and scientific papers
Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist
Okumura, Yoshiyuki,Yamagishi, Tatsuya,Nukui, Seiji,Nakao, Kazunari
, p. 1186 - 1192 (2017/06/21)
Starting from acylsufonamide HTS hit 2, a novel series of para-N-acylaminomethylbenzoic acids was identified and developed as selective prostaglandin EP4 receptor antagonists. Structural modifications on lead compound 4a were explored with the aim of impr
PHENYL OR PYRIDYL AMIDE COMPOUNDS AS PROSTAGLANDIN E2 ANTAGONISTS
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Page/Page column 82-83, (2015/03/06)
This invention provides a compound of the formula (I): wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R1 and R2 independently represent a hydrogen atom or the li
COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS
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Page/Page column 125, (2008/06/13)
The instant invention relates to a combination of an EP4-receptor antagonist and an alpha-2-delta ligand, and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly inflammatory,
