847740-59-4

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 14267-92-6 1-chloro-4-pentyne 
• 108-18-9 diisopropylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 70-55-3 toluene-4-sulfonamide 

Relevant academic research and scientific papers

Cu-catalyzed aerobic oxidative three-component coupling route to N -sulfonyl amidines via an ynamine intermediate

Cu-catalyzed aerobic oxidative three-component coupling of a terminal alkyne, secondary amine, and sulfonamide enables efficient synthesis of amidines. The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupling products. Preliminary studies suggest that the reaction pathway involves initial oxidative coupling of the terminal alkyne with the secondary amine, followed by hydroamidation of the ynamine intermediate with the sulfonamide.

Aerobic synthesis of N-sulfonylamidines mediated by N-heterocyclic carbene copper(I) catalysts

A new catalytic strategy for the one-pot synthesis of N-sulfonylamidines is described. The cationic copper(I) complexes were found to be highly active and efficient under mild conditions in air and in the absence of solvent. A copper acetylide is proposed as key intermediate in this transformation.

N-SULFONYL AMIDINE SYNTHESIS VIA THREE-COMPONENT COUPLING REACTION USING HETEROGENEOUS COPPER CATALYST

The present invention relates to a method of synthesizing N-sulfonyl amidine. More specifically, the present invention relates to the method of synthesizing N-sulfonyl amidine through a three-component coupling reaction using a heterogeneous copper catalyst; and optimization of reaction conditions applied thereto. The method is able to obtain corresponding N-sulfonyl amidine at high yield with respect to various substrates by performing a three-component coupling reaction of terminal alkyne, sulfonyl azide and amine by using a heterogeneous copper catalyst (Cu@C) obtained by pyrolyzing HKUST-1 which is a type of a metal-organic framework, and enables the heterogeneous copper catalyst to be reused at least four or more times without significant loss of catalytic activities since the heterogeneous copper catalyst has structural stability.COPYRIGHT KIPO 2018

N-Sulfonyl amidine synthesis via three-component coupling reaction using heterogeneous copper catalyst derived from metal-organic frameworks

Three-component coupling reaction of terminal alkyne, sulfonyl azide, and amine for the synthesis of N-sulfonyl amidine was developed using heterogeneous Cu@C catalyst, which was generated by pyrolysis of HKUST-1 (Cu3(BTC)2, BTC?=?1,

Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents

Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous