847774-91-8Relevant academic research and scientific papers
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity
Marcyk, Paul T.,Leblanc, Emmanuelle V.,Kuntz, Douglas A.,Xue, Alice,Ortiz, Francisco,Trilles, Richard,Bengtson, Stephen,Kenney, Tristan M. G.,Huang, David S.,Robbins, Nicole,Williams, Noelle S.,Krysan, Damian J.,Privé, Gilbert G.,Whitesell, Luke,Cowen, Leah E.,Brown, Lauren E.
, p. 1139 - 1169 (2021/02/01)
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics has be
N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors
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Page/Page column 10, (2008/06/13)
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
N-SUBSTITUTED PYRAZOLYL-AMIDYL-BENZIMIDAZOLYL C-KIT INHIBITORS
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Page/Page column 24, (2008/06/13)
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
