847801-39-2

Usage

Heterocyclic compound

Consists of a pyrrole ring fused to a pyridine ring

Carboxaldehyde group

Located at position 3 of the compound

Chlorine atom

Located at position 2 of the phenyl group

Potential applications

Pharmaceutical and agrochemical industries

Biological activities

Antitumor, antiviral, and antibacterial properties

Use as a building block

Can be used in organic synthesis for drug discovery and development.

Upstream product

• 127555-71-9 1,3-dihydro-1-phenyl-2H-pyrrolo[2,3-b]pyridine-2-one 
• 68-12-2 N,N-dimethyl-formamide 
• 591-50-4 iodobenzene 

Downstream Products

• 1175014-44-4 C₂₄H₂₂N₄O₂ 
• 1175014-46-6 C₂₅H₂₄N₄O₂ 
• 1175014-48-8 C₂₄H₂₁FN₄O₂ 
• 1175014-54-6 C₂₅H₂₃FN₄O₂ 
• 1175015-13-0 2-chloro-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 1175013-20-3 C₂₅H₂₃FN₄O₂ 
• 1175015-14-1 4-(2-chloro-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1175014-50-2 C₂₅H₂₃FN₄O₂ 
• 1175014-52-4 C₂₅H₂₂F₂N₄O₂ 
• 1175015-15-2 4-[2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1175015-16-3 4-(2-benzyl-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1175013-22-5 C₂₅H₂₄N₄O 
• 1175015-18-5 4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1175013-26-9 C₂₆H₂₅FN₄O 

Relevant academic research and scientific papers

Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds

The selective inhibition of the aspartyl protease renin is of high interest to control hypertension and associated cardiovascular risk factors. Following on preceding contributions, we report herein on the optimization of two series of azaindoles to arrive at potent and non-chiral renin inhibitors. The previously discovered azaindole scaffold was further explored by structure-based drug design in combination with parallel synthesis. This results in the identification of novel 5- or 7-azaindole derivatives with remarkable potency for renin inhibition. The best compounds on both series show IC50 values between 3 and 8 nM.

CYCLIC AZAINDOLE-3-CARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

The present invention relates to cyclic azaindole-3-carboxamides of the formula (I) wherein A, R, R10, R20, R30, R40, Y1, Y2, Y3, Y4, n, p and q have the meanings indi

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.