847818-58-0 Usage
Uses
Used in Organic Synthesis:
1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID is utilized as a versatile building block in organic synthesis for the preparation of a variety of pharmaceuticals and biologically active compounds. Its structural features facilitate the formation of diverse chemical entities with potential therapeutic applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID is employed as a key intermediate for the synthesis of drug candidates. Its incorporation into molecular frameworks can enhance pharmacological properties, such as potency, selectivity, and bioavailability.
Used as a Ligand in Transition Metal-Catalyzed Reactions:
1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID also serves as an effective ligand in transition metal-catalyzed reactions, which are pivotal in the synthesis of complex organic molecules. Its presence can modulate the reactivity and selectivity of these catalytic systems, enabling the efficient construction of desired molecular architectures.
Used in Suzuki-Miyaura Cross-Coupling Reactions:
The boronic acid functionality of 1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID allows it to participate in Suzuki-Miyaura cross-coupling reactions, a widely employed method in the synthesis of pharmaceuticals and agrochemicals. This reaction provides a robust and efficient means to form carbon-carbon bonds, facilitating the assembly of complex molecular structures with potential applications in various industries.
Used in Pharmaceutical Industry:
1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID is used as a synthetic precursor in the pharmaceutical industry for the development of new drugs. Its unique chemical properties and reactivity contribute to the discovery and optimization of drug candidates with improved therapeutic profiles.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(3-METHYLBUTYL)-1H-PYRAZOLE-4-BORONIC ACID is employed in the synthesis of agrochemicals, such as pesticides and herbicides. Its involvement in cross-coupling reactions enables the creation of novel active ingredients with enhanced efficacy and selectivity in agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 847818-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,7,8,1 and 8 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 847818-58:
(8*8)+(7*4)+(6*7)+(5*8)+(4*1)+(3*8)+(2*5)+(1*8)=220
220 % 10 = 0
So 847818-58-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H15BN2O2/c1-7(2)3-4-11-6-8(5-10-11)9(12)13/h5-7,12-13H,3-4H2,1-2H3
847818-58-0Relevant academic research and scientific papers
Synthesis of pinacol esters of 1-alkyl-1H-pyrazol-5-yl- and 1-alkyl-1H-pyrazol-4-ylboronic acids
Ivachtchenko, Alexandre V.,Kravchenko, Dmitry V.,Zheludeva, Valentina I.,Pershin, Dmitry G.
, p. 931 - 939 (2007/10/03)
Starting from 1H-pyrazol, a wide number of 1-alkyl-1H-pyrazol-4-yl and 1-alkyl-1H-pyrazol-5-ylboronic acids and their pinacol esters were synthesized and characterized. The key step in the described methodology is the regioselective lithiation of the pyrazole ring. The synthesized pinacolates are stable under prolonged storage and can be used as convenient reagents in organic synthesis.
