847835-01-2

Upstream product

• 847835-12-5 tert-butyl-[5-(6-[1,3]dioxolan-2-ylmethyl-3-methoxy-3,6-dihydro-2H-pyran-2-yl)-2-methylene-pentyloxy]-diphenyl-silane 
• 849361-69-9 1-(tert-butyl-diphenyl-silanyloxy)-5-(6-[1,3]dioxolan-2-ylmethyl-3-methoxy-3,6-dihydro-2H-pyran-2-yl)-pent-3-yn-2-ol 
• 847835-00-1 6-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienoic acid methyl ester 
• 849361-71-3 tert-butyl-[5-(3-methoxy-6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-2-methylene-pentyloxy]-diphenyl-silane 
• 849361-59-7 (2E,7E)-(S)-5-(4-Methoxy-benzyloxy)-8-((S)-4-methyl-3,6-dihydro-2H-pyran-2-yl)-6-oxo-octa-2,7-dienoic acid methyl ester 
• 847835-08-9 6-hydroxy-5-(4-methoxy-benzyloxy)-8-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-octa-2,7-dienoic acid methyl ester 
• 849361-66-6 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-[1,3]dioxolan-2-ylmethyl-3,6-dihydro-2H-pyran-3-ol 
• 847835-10-3 [3-(6-[1,3]dioxolan-2-ylmethyl-3-methoxy-3,6-dihydro-2H-pyran-2-yl)-prop-1-ynyl]-trimethyl-silane 
• 849361-58-6 6,7-dihydroxy-5-(4-methoxy-benzyloxy)-hept-2-enoic acid methyl ester 
• 849361-67-7 tert-butyl-(6-[1,3]dioxolan-2-ylmethyl-3-methoxy-3,6-dihydro-2H-pyran-2-ylmethoxy)-dimethyl-silane 
• 849361-72-4 5-(3-methoxy-6-prop-2-ynyl-3,6-dihydro-2H-pyran-2-yl)-2-methylene-pentan-1-ol 
• 847834-98-4 2-(4-bromomethyl-pent-4-enyl)-3-methoxy-6-prop-2-ynyl-3,6-dihydro-2H-pyran 
• 847834-93-9 acetic acid 2-acetoxymethyl-6-[1,3]dioxolan-2-ylmethyl-3,6-dihydro-2H-pyran-3-yl ester 
• 847834-95-1 6-[1,3]dioxolan-2-ylmethyl-2-(3-iodo-prop-2-ynyl)-3-methoxy-3,6-dihydro-2H-pyran 

Downstream Products

• 849361-74-6 4-{6-[6,11-bis-(tert-butyl-dimethyl-silanyloxy)-10-(4-methoxy-benzyloxy)-13-(4-methyl-3,6-dihydro-2H-pyran-2-yl)-4-methylene-trideca-7,12-dienyl]-5-methoxy-5,6-dihydro-2H-pyran-2-yl}-but-2-ynoic acid 

Relevant academic research and scientific papers

Synthesis of 8-(S)-methoxy-11-desmethyl laulimalide: A novel laulimalide analogue

A strategy is outlined which enables preparation of novel laulimalide analogues at C.8 and C.11. A representative analogue, 8-(S)-methoxy-11-desmethyl laulimalide, was synthesized via this route.

LAULIMALIDE ANALOGS AND USES THEREOF

The present invention provides compounds having formula 1: (I) and pharmaceutically acceptable derivatives thereof, wherein R1-R10, q, t, X0, X1, A, B, D, E, G, J, K, L, M and Z are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders associated with cellular hyperproliferation.