847862-98-0Relevant academic research and scientific papers
PRODUCTION METHOD OF 5-(TRIFLUOROMETHYL)PYRIMIDINE DERIVATIVE AND NOVEL 5-(TRIFLUOROMETHYL)PYRIMIDINE DERIVATIVE
-
Paragraph 0075; 0076, (2016/10/20)
PROBLEM TO BE SOLVED: To provide a production method of 5-(trifluoromethyl)pyrimidine derivative which enables introduction of an aniline derivative to the 2- or 4-position of the pyrimidine ring with high selectivity, with the derivative being useful as
2-SUBSTITUTED-4-(2,2,2-TRIFLUOROETHOXY)-5-(TRIFLUOROMETHYL)PYRIMIDINE DERIVATIVE AND PRODUCTION METHOD THEREOF
-
Paragraph 0054; 0055, (2016/10/07)
PROBLEM TO BE SOLVED: To provide 2-substituted-4-(2,2,2-trifluoroethoxy)-5-(trifluoromethyl)pyrimidine derivative of formula (1) useful as a medical and agrichemical intermediate and an intermediate for electronic material intermediate and its production
Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids
Richter, Daniel T.,Kath, John C.,Luzzio, Michael J.,Keene, Nandell,Berliner, Martin A.,Wessel, Matthew D.
supporting information, p. 4610 - 4612 (2013/08/23)
A variety of 2,4-diamino-pyrimidine systems can be prepared from the corresponding 2,4-dichloro-pyrimidine by sequential addition of two amines, the first adding selectively to the 4-position. In contrast it was found that 2,4-dichloro-5-trifluoromethyl-p
SELECTIVE SYNTHESIS OF CF3-SUBSTITUTED PYRIMIDINES
-
Page/Page column 9-10, (2008/06/13)
The present invention relates to a method of making a compound of the formula (I),wherein X1, X2 and R3-R4 are as defined herein. The method includes reacting a compound of the formula (II) with an amine of formula (III) (HNR33R44) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the 10 treatment of abnormal cell growth, such as cancer, in mammals.
