847863-05-2Relevant academic research and scientific papers
Selective addition of amines to 5-trifluoromethyl-2,4-dichloropyrimidine induced by Lewis acids
Richter, Daniel T.,Kath, John C.,Luzzio, Michael J.,Keene, Nandell,Berliner, Martin A.,Wessel, Matthew D.
supporting information, p. 4610 - 4612 (2013/08/23)
A variety of 2,4-diamino-pyrimidine systems can be prepared from the corresponding 2,4-dichloro-pyrimidine by sequential addition of two amines, the first adding selectively to the 4-position. In contrast it was found that 2,4-dichloro-5-trifluoromethyl-p
SELECTIVE SYNTHESIS OF CF3-SUBSTITUTED PYRIMIDINES
-
Page/Page column 11, (2008/06/13)
The present invention relates to a method of making a compound of the formula (I),wherein X1, X2 and R3-R4 are as defined herein. The method includes reacting a compound of the formula (II) with an amine of formula (III) (HNR33R44) in the presence of a Lewis Acid and a non-nucleophilic base. The 2,4-diamino pyrimidine moiety is a common component in a variety of biologically active drug-like molecules and pyrimidine derivatives have been found to be useful in the 10 treatment of abnormal cell growth, such as cancer, in mammals.
