84794-40-1

Upstream product

• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 
• 60-18-4 L-tyrosine 

Downstream Products

• 27220-68-4 Boc-Ala-Tyr-N₂H₃ 
• 144006-24-6 Ala-Tyr-OMe 
• 84794-41-2 Boc-Ala-Ala-Tyr-OMe 
• 84794-45-6 Ac-Ala-Ala-Ala-Tyr-OMe 
• 84794-43-4 Boc-Ala-Ala-Ala-Tyr-OMe 
• 86961-40-2 Boc-Ala-Tyr-Leu-OH 
• 86961-34-4 Boc-Ala-Tyr-Leu-Val-CH₂Cl 
• 132149-69-0 (8S,11S,14S)-14-Benzyloxycarbonylamino-3,19-dihydroxy-11-methyl-10,13-dioxo-9,12-diaza-tricyclo[14.3.1.1^2,6]henicosa-1⁽²⁰⁾,2,4,6⁽²¹⁾,16,18-hexaene-8-carboxylic acid methyl ester 
• 1374840-28-4 (S)-methyl 2-((S)-2-aminopropanamido)-3-(4-hydroxyphenyl)propanoate trifluoroacetate 

Relevant academic research and scientific papers

Tyrosine-Specific Modification via a Dearomatization-Rearomatization Strategy: Access to Azobenzene Functionalized Peptides

Azobenzene functionalized peptides are of great importance in photoresponsive biosystems and photopharmacology. Herein, we report an efficient approach to prepare azobenzene functionalized peptides through late-stage modification of tyrosine-containing peptides using a dearomatization-rearomatization strategy. This approach shows good chemoselectivity and site selectivity as well as sensitive group tolerance to various peptides. This method enriches the postsynthetic modification toolbox of peptides and has great potential to be applied in medicinal chemistry and chemical biology.

Serine-Protease-Assisted Synthesis of Peptide Substrates for α-Chymotripsin

δ-Chymotrypsin catalyzes peptide-bond formation between acylated amino-acid and peptide esters as the carboxyl component and amino-acid and peptide amides as the amino component.The conditions under which enzyme-catalyzed coupling can be used for fragment condensation in peptide synthesis is investigated.To illustrate the method the synthesis of tetra-, penta and hexapeptides of the structure Ac-Lxn-...-Lxl-Lyl-...-Lym-NH2 with Lxl = Tyr, designed as substrates for α-chymotrypsin is described.