84794-72-9Relevant academic research and scientific papers
Synthesis and anticancer activity studies on some 2-chloro-1,4-bis-(5- substituted-1,3,4-oxadiazol-2-ylmethyleneoxy) phenylene derivatives
Holla, B. Shivarama,Poojary, K. Narayana,Bhat, K. Subrahmanya,Ashok, Mithun,Poojary, Boja
, p. 1669 - 1673 (2007/10/03)
2-Chloro-1,4-phenylenedioxy-bis-acetyl hydrazine 1 on reacting with aromatic carboxylic acids in the presence of phosphorus oxychloride affords 2-chloro-bis-1,3,4-oxadiazoles 3a-f and 4a-d. Aroyl hydrazine 1 on reacting with carbon disulphide under basic
New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents
Shivarama Holla,Narayana Poojary,Sooryanarayana Rao,Shivananda
, p. 511 - 517 (2007/10/03)
A series of bis-phenoxyacetic acids 2 were prepared starting from corresponding unsubstituted/substituted 1,4-quinols 1. The fusion of bis-phenoxyacetic acids 2 with thiocarbohydrazide gave the corresponding bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl-methyleneoxy]phenylenes (3) in a one pot reaction. The reaction of bis-triazoles 3 with various reagents afforded N-bridged heterocycles 4-6 in good yields. The newly synthesised compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia. Some of the tested compounds showed promising anticancer properties.
