847972-30-9Relevant academic research and scientific papers
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: Structure-based drug design, synthesis, and biological evaluation
Vernier, William,Chong, Wesley,Rewolinski, David,Greasley, Samantha,Pauly, Thomas,Shaw, Morena,Dinh, Dac,Ferre, Rose Ann,Nukui, Seiji,Ornelas, Martha,Reyner, Eric
experimental part, p. 3307 - 3319 (2010/07/10)
A novel series of potent thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV was discovered using structure-based drug design. Synthesis, structure-activity relationship, and optimization of physicochemical properties are described. Low nanomolar potency was achieved, and selected compounds with improved thermodynamic solubility showed promising in vitro inhibition of carbonic anhydrase activity in rabbit iris ciliary body homogenate.
IL-8 RECEPTOR ANTAGONISTS
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Page/Page column 31, (2008/12/06)
This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES
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Page/Page column 144, (2008/06/13)
A compound of formula (I) wherein the substituents are described in claim 1 for the treatment of psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
