847978-05-6Relevant articles and documents
8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8- isopropyl-adenine: Highly potent and selective PDE4 inhibitors
Whitehead, John W. F.,Lee, Gary P.,Gharagozloo, Parviz,Hofer, Peter,Gehrig, André,Wintergerst, Peter,Smyth, Donald,McCoull, William,Hachicha, Mohamed,Patel, Aniket,Kyle, Donald J.
, p. 1237 - 1243 (2007/10/03)
3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine V11294 (1) has been identified as a lead structure, which selectively inhibits human lung PDE4 (436 nM) and is also active in a number of in vitro and in vivo models of inflammation. Here we descri