848-63-5Relevant articles and documents
CHEMISTRY OF 3-BETA,12-DIHYDROXY-5-ALPHA-ANDROSTAN-17-ONES.
NAMBARA
, p. 1253 - 1258 (1964)
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Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes
See, Yi Yang,Herrmann, Aaron T.,Aihara, Yoshinori,Baran, Phil S.
supporting information, p. 13776 - 13779 (2016/01/15)
Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chemical method addresses this challenge in a low-yielding and not fully understood fashion: Sch?necker's Cu-mediated oxidation. This work shines new light onto this powerf
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Zietz,Spiteller
, p. 585 - 596 (2007/10/15)
Mass spectrometric degradation reactions of steroids with hydroxy groups in positions 12 and 17β depend on the configuration of the C-12 hydroxy group. In compounds with a 12α-hydroxy group, this group and the hydrogen in position 17α is eliminated as H2O. This reaction is followed by loss of a methyl radical. In the isomers with a 12β-hydroxy group this reaction is not possible. Here the loss of carbon 15-17 dominates the production of an ion by loss of two molecules of water. Key ions of mass 97 as well as M-44 and M-74 ions are produced by 17 keto steroids with a hydroxy group in position 12. If the rings A and B are cis-connected less specific degradation reactions are observed.