848-63-5Relevant academic research and scientific papers
C7, C12, AND C16 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE
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Page/Page column 164, (2018/03/26)
Described herein are neuroactive steroids of Formula (I), Formula (V), or Formula (IX) or a pharmaceutically acceptable salt thereof; wherein each instance of R2, R3, R4, R5, R6, R7, R11a, R11b,R12, R16, R17, R19, and ----- are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.
Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes
See, Yi Yang,Herrmann, Aaron T.,Aihara, Yoshinori,Baran, Phil S.
supporting information, p. 13776 - 13779 (2016/01/15)
Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chemical method addresses this challenge in a low-yielding and not fully understood fashion: Sch?necker's Cu-mediated oxidation. This work shines new light onto this powerf
Enantioselective synthesis of (+)-cephalostatin 1
Fortner, Kevin C.,Kato, Darryl,Tanaka, Yoshiki,Shair, Matthew D.
supporting information; experimental part, p. 275 - 280 (2010/03/25)
This Article describes an enantioselective synthesis of cephalostatin 1. Key steps of this synthesis are a unique methyl group selective allylic oxidation, directed C-H hydroxylation of a sterol at C12, Au(I)-catalyzed 5-endo-dig cyclization, and a kinetic spiroketalization.
