848002-01-7Relevant academic research and scientific papers
Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists
Cherney, Robert J.,Mo, Ruowei,Yang, Michael G.,Xiao, Zili,Zhao, Qihong,Mandlekar, Sandhya,Cvijic, Mary Ellen,Charo, Israel F.,Barrish, Joel C.,Decicco, Carl P.,Carter, Percy H.
, p. 1843 - 1845 (2014/04/17)
We describe novel alkylsulfones as potent CCR2 antagonists with reduced hERG channel activity and improved pharmacokinetics over our previously described antagonists. Several of these new alkylsulfones have a profile that includes functional antagonism of
