848004-66-0

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 628-77-3 1,5-diiodopentane 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 145325-48-0 1',5'-bis(4-carboxy-2-methoxy-5-nitrophenoxy)pentane 
• 3030-32-8 4,4’-(pentane-1,5-diylbis(oxy))bis(3-methoxybenzoic acid) 

Downstream Products

• 848004-70-6 ((pentane-1,5-diylbis(oxy))bis(2-amino-5-methoxy-4,1-phenylene))bis(((S)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)methanone) 
• 848004-68-2 ((pentane-1,5-diylbis(oxy))bis(5-methoxy-2-nitro-4,1-phenylene))bis(((S)-2-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-1-yl)methanone) 

Relevant academic research and scientific papers

CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

PYRROLOBENZODIAZEPINE CONJUGATES

A compound of formula I and salts and solvates thereof, wherein: R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo; where R and R' are independently selected f

SYNTHESIS OF PROTECTED PYRROLOBENZODIAZEPINES

A method of synthesis of a N-10 protected PBD compound of formula (I) via an intermediate of formula (II) or formula (V).