848006-35-9

Basic information

• Product Name: 3-(4-BROMO-PHENYL)-1H-PYRROLE
• Synonyms: 3-(4-BROMO-PHENYL)-1H-PYRROLE
• CAS NO: 848006-35-9
• Molecular Formula: C10H8BrN
• Molecular Weight: 0
• Mol File: 848006-35-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 355.389°C at 760 mmHg
• Flash Point: 168.734°C
• Appearance: /
• Density: 1.488g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 3-(4-BROMO-PHENYL)-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-BROMO-PHENYL)-1H-PYRROLE(848006-35-9)
• EPA Substance Registry System: 3-(4-BROMO-PHENYL)-1H-PYRROLE(848006-35-9)

Safety Data

• Hazardous Substances Data: 848006-35-9(Hazardous Substances Data)

Usage

General Description

3-(4-Bromo-phenyl)-1H-pyrrole is a chemical compound with a molecular formula of C10H8BrN. It is a pyrrole derivative with a bromine atom attached to the fourth position of the phenyl group. 3-(4-BROMO-PHENYL)-1H-PYRROLE is commonly used as a building block in organic synthesis and medicinal chemistry. It has been studied for its potential biological activities and pharmacological properties, including its antifungal and antitumor effects. Additionally, 3-(4-Bromo-phenyl)-1H-pyrrole may also be used in the development of new materials and as a starting material for the synthesis of other complex organic compounds.

InChI:InChI=1/C10H8BrN/c11-10-3-1-8(2-4-10)9-5-6-12-7-9/h1-7,12H

Upstream product

• 3650-78-0 methyl 4-bromocinnamate 
• 24393-53-1 ethyl 4-bromocinnamate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 1122-91-4 4-bromo-benzaldehyde 

Relevant articles and documents

Metal-Free Directed C?H Borylation of Pyrroles

Robust strategies to enable the rapid construction of complex organoboronates in selective, practical, low-cost, and environmentally friendly modes remain conspicuously underdeveloped. Here, we develop a general strategy for the site-selective C?H borylation of pyrroles by using only BBr3 directed by pivaloyl groups, avoiding the use of any metal. The site-selectivity is generally dominated by chelation and electronic effects, thus forming diverse C2-borylated pyrroles against the steric effect. The formed products can readily engage in downstream transformations, enabling a step-economic process to access drugs such as Lipitor. DFT calculations (wB97X-D) demonstrate the preferred positional selectivity of this reaction.

Construction of the Bacteriochlorin Macrocycle with Concomitant Nazarov Cyclization To Form the Annulated Isocyclic Ring: Analogues of Bacteriochlorophyll a

Bacteriochlorophylls contain a bacteriochlorin macrocycle bearing an annulated fifth ring. The fifth ring, termed the isocyclic ring or ring E, is equipped with 131-oxo and 132-carbomethoxy substituents. Herein, a general route to st